Thomas O'Connell Selected Research

CP533536

10/2008

CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance.

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Thomas O'Connell Research Topics

Disease

2	Migraine Disorders (Migraine) 10/2021 - 10/2021
1	Headache (Headaches) 10/2021
1	Secondary Headache Disorders 10/2021
1	Hemolysis 01/2020
1	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 01/2020
1	Venous Thrombosis (Deep-Vein Thrombosis) 01/2020
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2019
1	Substance-Related Disorders (Drug Abuse) 01/2013
1	Bone Fractures (Bone Fracture) 10/2008
1	Insulin Resistance 09/2002
1	Acromegaly 09/2002

Drug/Important Bio-Agent (IBA)

1	eculizumab FDA Link 01/2020
1	Complement System Proteins (Complement)IBA 01/2020
1	ravulizumabIBA 01/2020
1	acylcarnitineIBA 01/2019
1	Amino Acids FDA Link 01/2019
1	Antipsychotic Agents (Antipsychotics)IBA 01/2013
1	pyridineIBA 10/2008
1	CP533536IBA 10/2008
1	Dinoprostone (PGE2)FDA Link 10/2008
1	Acetic Acid (Vinegar)FDA LinkGeneric 10/2008
1	Insulin (Novolin)FDA Link 09/2002
1	Insulin-Like Growth Factor I (IGF-1)IBA 09/2002

Therapy/Procedure

2	Therapeutics 10/2021 - 10/2021
1	Ambulatory Care (Outpatient Care) 10/2021
1	Blood Transfusion (Blood Transfusions) 01/2020
1	Aftercare (After-Treatment) 09/2002